O2 Protocol Statistical Justification
Executive Summary¶
This analysis provides statistical comparison of feeding patterns between infants with and without respiratory support at 36 weeks PMA. The analysis examined 228 infants (60 with O2 support, 168 without O2 support).
Key Findings:¶
Statistical Evidence Summary: Current analysis did not identify strong statistical differences between O2 groups in feeding timing patterns. Results provide baseline for future studies with larger sample sizes.
Group Difference Testing¶
Summary Statistics by Group:
| n | n_missing | mean | median | std | min | max | q1 | q3 | iqr | |
|---|---|---|---|---|---|---|---|---|---|---|
| O2 Support | 60 | 0 | 20.6432 | 18.9792 | 12.8067 | 1.33333 | 54.6292 | 11.1495 | 28 | 16.8505 |
| No O2 Support | 168 | 0 | 14.1744 | 10.8646 | 12.8741 | 0 | 74.625 | 5.45903 | 18.7938 | 13.3347 |
Unadjusted Group Comparison: - Mean difference: 6.47 days - t-statistic: 3.346 - p-value: 0.0010 - Cohen's d: 0.000 - 95% CI: [2.67, 10.27]
Adjusted Group Comparison (controlling for GA, birth weight, medical complexity): - O2 Support adjusted mean: 18.31 days - No O2 Support adjusted mean: 15.01 days - Adjusted difference: 3.30 days - Regression coefficient: 1.453 - Sample size: 228 subjects
Optimal Timing Analysis by Group¶
O2 Support (n=60): - Status: No significant quadratic relationship - p-value: 1.0000
No O2 Support (n=168): - Status: No significant quadratic relationship - p-value: 1.0000
Slope Differences at PMA Cutpoints¶
34 Weeks: - O2 Support: Early slope=0.184 (n=20), Late slope=-0.098 (n=40), Difference=-0.283 - No O2 Support: Early slope=-0.339 (n=90), Late slope=0.247 (n=78), Difference=0.587 35 Weeks: - O2 Support: Early slope=-0.150 (n=33), Late slope=-0.129 (n=27), Difference=0.021 - No O2 Support: Early slope=-0.204 (n=133), Late slope=0.276 (n=35), Difference=0.481 36 Weeks: - O2 Support: Early slope=-0.128 (n=46), Late slope=0.285 (n=14), Difference=0.414 - No O2 Support: Early slope=-0.163 (n=158), Late slope=0.027 (n=10), Difference=0.190
Statistical Summary¶
Statistical Evidence Summary: Current analysis did not identify strong statistical differences between O2 groups in feeding timing patterns. Results provide baseline for future studies with larger sample sizes.
Statistical Evidence Summary¶
Statistical Evidence for Group Differences:
-
Group Differences: Significant difference in time to full oral feeding between groups
-
Optimal Timing: Similar or unclear optimal timing relationships between groups
-
Interaction Effects: Not significant interaction between feeding timing and O2 support status
-
Statistical Significance: Effect sizes and group differences provide limited statistical evidence for group distinctions
Publication-Ready Evidence Table:
| Analysis Component | O2 Support Group | No O2 Support Group | Statistical Test | p-value | Effect Size | Statistical Significance |
|---|---|---|---|---|---|---|
| Time to FOF (mean±SD) | 20.6±12.8 | 14.2±12.9 | Independent t-test | 0.0010 | d=0.00 | Small |
| Optimal PMA (weeks) | N/A | N/A | Quadratic regression | Combined models | R² values reported | Similar patterns |