Primary Analysis: pma_at_first_oral_feeding vs time_to_fof¶
Analysis of pma_at_first_oral_feeding vs time_to_fof.
Unadjusted Model Results¶
Simple linear regression examining the direct relationship between pma_at_first_oral_feeding and time_to_fof.
Model diagnostics warning: High multicollinearity detected (condition number > 30). Residuals may not be normally distributed (p < 0.05).
Outcome: time_to_fof Predictor: pma_at_first_oral_feeding
OLS Regression Results
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Dep. Variable: time_to_fof R-squared: 0.000
Model: OLS Adj. R-squared: -0.004
Method: Least Squares F-statistic: 0.008884
Date: Tue, 05 Aug 2025 Prob (F-statistic): 0.925
Time: 04:28:07 Log-Likelihood: -910.30
No. Observations: 228 AIC: 1825.
Df Residuals: 226 BIC: 1831.
Df Model: 1
Covariance Type: nonrobust
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coef std err t P>|t| [0.025 0.975]
---------------------------------------------------------------------------------------------
const 13.9631 20.322 0.687 0.493 -26.082 54.008
pma_at_first_oral_feeding 0.0557 0.591 0.094 0.925 -1.109 1.220
==============================================================================
Omnibus: 56.850 Durbin-Watson: 1.443
Prob(Omnibus): 0.000 Jarque-Bera (JB): 99.661
Skew: 1.316 Prob(JB): 2.29e-22
Kurtosis: 4.888 Cond. No. 802.
==============================================================================
Notes:
[1] Standard Errors assume that the covariance matrix of the errors is correctly specified.
Unadjusted Plot¶
Plot showing relationship between pma_at_first_oral_feeding and time_to_fof (LOESS with CI and OLS prediction).
Model Variables (Adjusted Analysis)¶
Outcome: time_to_fof Indep: pma_at_first_oral_feeding Gestational Age Var: gestational_age_weeks Confounders: ['gestational_age_weeks', 'birth_weight_grams', 'mechanical_ventilation', 'o2_device_at_36_weeks'] Covariates: ['medicalcomplexity']
Adjusted Model Results¶
Multiple regression examining the relationship between pma_at_first_oral_feeding and time_to_fof, controlling for gestational age and other potential confounders.
Model diagnostics warning: High multicollinearity detected (condition number > 30). Residuals may not be normally distributed (p < 0.05).
Outcome: time_to_fof Predictors: pma_at_first_oral_feeding, gestational_age_weeks, birth_weight_grams, mechanical_ventilation_no history of mechanical ventilation, o2_device_at_36_weeks_did NOT require respiratory support at 36 weeks, medicalcomplexity_Children with noncomplex chronic disease, medicalcomplexity_Children without chronic disease
OLS Regression Results
==============================================================================
Dep. Variable: time_to_fof R-squared: 0.137
Model: OLS Adj. R-squared: 0.109
Method: Least Squares F-statistic: 4.978
Date: Tue, 05 Aug 2025 Prob (F-statistic): 3.00e-05
Time: 04:28:09 Log-Likelihood: -893.54
No. Observations: 228 AIC: 1803.
Df Residuals: 220 BIC: 1831.
Df Model: 7
Covariance Type: nonrobust
=========================================================================================================================================
coef std err t P>|t| [0.025 0.975]
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const 90.1802 26.873 3.356 0.001 37.219 143.142
pma_at_first_oral_feeding -1.3018 0.619 -2.103 0.037 -2.522 -0.082
gestational_age_weeks -0.6582 0.806 -0.817 0.415 -2.246 0.930
birth_weight_grams -0.0033 0.004 -0.775 0.439 -0.012 0.005
mechanical_ventilation_no history of mechanical ventilation -5.2261 2.045 -2.556 0.011 -9.256 -1.196
o2_device_at_36_weeks_did NOT require respiratory support at 36 weeks -2.3154 2.160 -1.072 0.285 -6.572 1.942
medicalcomplexity_Children with noncomplex chronic disease -1.1028 4.974 -0.222 0.825 -10.905 8.699
medicalcomplexity_Children without chronic disease -2.2645 3.915 -0.578 0.564 -9.979 5.450
==============================================================================
Omnibus: 85.427 Durbin-Watson: 1.649
Prob(Omnibus): 0.000 Jarque-Bera (JB): 245.956
Skew: 1.646 Prob(JB): 3.90e-54
Kurtosis: 6.880 Cond. No. 4.23e+04
==============================================================================
Notes:
[1] Standard Errors assume that the covariance matrix of the errors is correctly specified.
[2] The condition number is large, 4.23e+04. This might indicate that there are
strong multicollinearity or other numerical problems.
Adjusted Plot¶
Plot showing adjusted relationship between pma_at_first_oral_feeding and time_to_fof (LOESS with CI).
Relationship Analysis¶
Adjusted plot shows relationship.