Time to FOF Quality Control

Quality assessment of feeding timeline variables and identification of potential data issues.

Variable Definitions

• time_to_first: Days from birth to first oral feeding
• time_to_fof: Days from birth to full oral feeding
• feed_delta: Days from first oral feeding to full oral feeding (for QC purposes)

Data Quality Issues Identified

• 4 cases (1.8%) where feed_delta < 0 (full feeding achieved before first oral feeding)
• 8 cases (3.5%) where feed_delta < 1 day (achieved full feeding within 24 hours)

Summary Statistics

	Variable	N	Missing	Mean	SD	Min	Median	Max
0	time_to_first	228	0	40.9	20.5	1.3	38.2	108.3
1	time_to_fof	228	0	15.9	13.1	0	13	74.6
2	feed_delta	228	0	15.9	13.1	-0.9	13	74.6

Distribution of Time to FOF

Distribution of Feed Delta

Relationship Analysis

Flagged Cases (Negative Feed Delta)

Showing 4 of 4 cases with negative feed delta:

time_to_first	time_to_fof	feed_delta
17.6	0	-0.2
30.3	0	-0.1
30.3	0	-0.1
33.6	0	-0.9

Questions for Principal Investigator

1. Data Cleaning: Should cases with negative feed_delta (full feeding before first feeding) be excluded as data errors?

2. Same-Day Achievement: How should cases achieving full feeding within 24 hours be handled in analyses?

3. Missing Values: What is the appropriate handling for missing time_to_FOF values?

4. Outliers: Should extreme values (e.g., time_to_FOF > 100 days) be investigated or excluded?